Pericardial window procedures are commonly performed for the management of recurrent or symptomatic pericardial effusion. Multiple surgical approaches are currently utilized, including pericardioperitoneal window (PPW), pleuropericardial window (PLW), and regular subxiphoid pericardial window procedures. However, comparative data evaluating perioperative outcomes among these techniques remain limited. This study aimed to compare perioperative outcomes and postoperative complications across the three surgical approaches.
A retrospective exploratory cohort study was conducted in Jordan University Hospital and King Abdullah University Hospital, including patients who underwent surgical pericardial window creation. Patients were divided into three groups: PPW, PLW, and regular pericardial window. Baseline characteristics, perioperative variables, postoperative complications, and length-of-stay outcomes were analyzed descriptively and comparatively. Continuous variables were reported as median [IQR], and categorical variables as n/N (%). Fisher’s exact and Wilcoxon rank-sum tests were used where appropriate. Effect estimates were reported with 95% confidence intervals.
The study cohort included 28 patients, of whom 5 underwent PPW, 7 underwent PLW, and 16 underwent regular pericardial window procedures. Median age was 55 [38–65] years in the PPW group, 52 [29–55] years in the PLW group, and 52 [36.5–58] years in the regular pericardial window group. Early 30-day complications occurred in 3/5 (60.0%) PPW patients, 5/7 (71.4%) PLW patients, and 1/16 (6.2%) regular pericardial window patients. Acute complications occurred in 40.0%, 57.1%, and 12.5% of patients, respectively. PLW demonstrated numerically shorter hospital length of stay, shorter ICU stay, lower estimated blood loss, and shorter chest tube duration compared with PPW, while the regular pericardial window group demonstrated the lowest documented early complication rate. However, no continuous perioperative outcome demonstrated a statistically conclusive difference across groups. Long-term outcomes were limited by sparse follow-up documentation.
In this exploratory three-group retrospective cohort study, no definitive superiority of any individual surgical approach was established. The regular pericardial window group demonstrated the lowest documented early complication rate, whereas PLW showed numerically favorable perioperative recovery characteristics in several outcomes. Interpretation of these findings is limited by the retrospective design, small sample size, baseline imbalance between groups, and incomplete long-term follow-up. Larger prospective multicenter studies are needed to better define comparative safety, recurrence risk, and long-term effectiveness among different pericardial window techniques.
Keywords: Pericardial Effusion; Pericardial Window; Pericardioperitoneal Window; Pleuropericardial Window; Perioperative Outcomes; Postoperative Complications; Retrospective Cohort Study