The Journal of Molecular Biology publishes high-quality original research articles, reviews, short communications, case studies, and technical notes spanning all major domains of molecular biology and modern biomolecular sciences. We welcome submissions across (but not limited to) the following thematic areas:

Molecular Structure, Dynamics & Biophysics

• Structure and function of proteins, nucleic acids, and macromolecular complexes
• Molecular folding, misfolding, aggregation, and stability
• Protein and RNA dynamics, conformational changes, and energy landscapes
• Cryo-EM, X-ray crystallography, NMR spectroscopy, and single-molecule methods
• Computational modeling, molecular dynamics simulations, structural prediction

Genetics, Genomics & Chromosome Biology

• Gene structure, regulation, and expression
• Genome organization, chromatin architecture, epigenetics, and nuclear dynamics
• High-throughput sequencing, comparative genomics, and population genomics
• Transcriptional control, enhancer biology, and noncoding regulatory elements
• Genetic variation, mutation, recombination, and genome evolution

Molecular Cell Biology

• Cellular signaling pathways and molecular regulatory networks
• Membrane trafficking, organelle dynamics, and cytoskeletal organization
• Cell cycle regulation, DNA replication, repair, and recombination
• Apoptosis, autophagy, senescence, and cellular stress responses
• Cell–cell communication, adhesion, and extracellular matrix interactions

RNA Biology & Gene Regulation

• RNA structure, modification, and function
• Ribosome biology, translation mechanisms, and translational control
• Noncoding RNAs (miRNA, siRNA, lncRNA, circRNA), RNA processing, splicing
• Regulatory RNA networks in development, physiology, and disease
• RNA–protein interactions and RNP complex biology

Proteomics, Metabolomics & Systems Biology

• Proteomic profiling, post-translational modifications, and protein networks
• Metabolomic pathways, metabolic regulation, and biochemical flux analysis
• Quantitative systems biology, network modeling, and data integration
• Multi-omics approaches for functional characterization
• High-throughput technologies and computational biology

Molecular Pathways in Health & Disease

• Molecular mechanisms underlying human diseases
• Oncogenesis, tumor suppressors, signaling dysregulation
• Neurodegenerative, metabolic, cardiovascular, and immune-related disorders
• Host–pathogen interactions at the molecular level
• Biomarker discovery and molecular therapeutic targets

Molecular Biotechnology & Synthetic Biology

• Genetic engineering, gene editing (CRISPR/Cas, base editors, prime editing)
• Molecular cloning, vector design, and recombinant DNA technology
• Synthetic circuits, gene constructs, genome rewriting
• Biomolecular engineering, protein design, and directed evolution
• Industrial, agricultural, environmental, and biomedical biotechnology applications

Bioinformatics, Computational Molecular Biology & AI

• Computational tools for molecular sequence, structure, and interaction analysis
• Machine learning and AI in molecular prediction and design
• Algorithm development, data mining, and biomolecular simulation
• Computational genomics, transcriptomics, and molecular modeling
• Big data analytics and digital molecular biology

Molecular Microbiology & Virology

• Bacterial, archaeal, viral, and microbial eukaryote molecular mechanisms
• Microbial gene regulation, quorum sensing, and metabolic pathways
• Virus structure, replication, host manipulation, and antiviral strategies
• Microbial genomics, pathogenesis, and molecular immunity

Chemical Biology & Biochemical Mechanisms

• Enzyme structure, mechanisms, and catalytic regulation
• Signal transduction cascades and molecular switches
• Small molecules, molecular probes, and chemical modulators of biology
• Natural product mechanisms and bioactive compound discovery
• Molecular interactions, binding kinetics, and energetics

Emerging & Interdisciplinary Molecular Technologies

• Nanobiotechnology, molecular sensors, and biomimetic systems
• High-throughput screening, microfluidics, lab-on-chip technologies
• Single-cell sequencing, spatial omics, and advanced imaging
• Molecular diagnostics, therapeutics, biologics, and precision medicine
• Ethics, policy, biosafety, and responsible innovation in molecular biology