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IDH1 and IDH2 Gene Role in Glioma
Commentary - Volume: 1, Issue: 2, 2026 (January)
IDH1 and IDH2 Gene Role in Glioma Download PDF
Abrar Hussain*
Department of Biological Sciences, International Islamic University, Islamabad, Pakistan
*Correspondence to: Abrar Hussain, Department of Biological Sciences, International Islamic University, Islamabad, Pakistan. E-Mail:
Received: August 18, 2025; Manuscript No: JMBC-25-1396; Editor Assigned: August 20, 2025; PreQc No: JMBC-25-1396(PQ); Reviewed: August 22, 2025; Revised: August 28, 2025; Manuscript No: JMBC-25-1396(R); Published: January 02, 2026

INTRODUCTION

Metabolic gene mutations are increasingly recognized as key drivers of tumorigenesis across various cancer types, including gliomas. These mutations impair normal cellular metabolism and disrupt crucial regulatory processes that maintain epigenetic stability. In particular, genes such as Fumarate Hydratase (FH) and Succinate Dehydrogenase Complex Subunit C (SDHC) have been implicated in a subset of hereditary and sporadic cancers, where their loss leads to the accumulation of metabolic intermediates with oncogenic potential [1-2].
Citation: Hussain A (2026). IDH1 and IDH2 Gene Role in Glioma. J. Mol. Biol. Vol.1 Iss.2, January (2026), pp:7-9.
Copyright: © 2026 Hussain A. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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