Microfluidics and Lab-on-a-Chip (LOC) devices represent cutting-edge innovations in miniaturized analytical systems. Microfluidics involves the precise control and manipulation of fluids at the microscale, enabling complex chemical and biological processes to occur in compact spaces. Lab-on-a-Chip devices integrate multiple laboratory functions such as sample preparation, mixing, reaction, and detection onto a single chip, reducing the need for large-scale equipment. These technologies offer rapid analysis, reduced reagent consumption, and cost-effective solutions, making them highly valuable in diagnostics, drug development, environmental testing, and personalized medicine. Their portability and efficiency are transforming point-of-care testing and enabling real-time, on-site analysis. With ongoing advancements, Microfluidics and LOC systems continue to enhance the speed, accessibility, and precision of analytical procedures across a wide range of scientific disciplines.