The Journal of Stem Cells and Tissue Engineering publishes original research articles, reviews, short communications, case studies, and technical notes covering all major areas of stem cell science, regenerative medicine, and tissue engineering. Submissions are welcome across the following thematic domains (but not limited to):

Stem Cell Biology & Fundamental Stem Cell Science

• Stem cell identity, potency, and lineage specification
• Self-renewal, differentiation mechanisms, and cell fate regulation
• Genomic, epigenomic, and transcriptomic control of stem cells
• Stem cell niches, microenvironment, and signaling pathways
• Cellular reprogramming, pluripotency, and induced pluripotent stem cells (iPSCs)

Embryonic, Adult & Induced Pluripotent Stem Cells

• Embryonic stem cell (ESC) maintenance and differentiation
• Adult stem cells: mesenchymal, hematopoietic, neural, epithelial, and cardiac
• iPSC technology, disease modeling, and personalized cell therapies
• Comparative stem cell biology across species
• Ethical, regulatory, and safety issues in stem cell research

Regenerative Medicine & Translational Stem Cell Therapy

• Stem cell–based regenerative strategies for tissue and organ repair
• Clinical-grade stem cell processing, GMP manufacturing, and transplantation
• Stem cell therapy for degenerative, metabolic, neurological, and cardiovascular diseases
• Immunomodulation, immune compatibility, and host–graft interactions
• Preclinical models, translational protocols, and clinical trial developments

Tissue Engineering & Biomaterial Science

• Scaffold design, biomaterials, and nanomaterials for tissue regeneration
• Hydrogels, biopolymers, and bioactive matrices
• Tissue scaffolds for bone, cartilage, skin, nerve, liver, and cardiac repair
• Biodegradable materials, biofabrication, and smart biomaterials
• Material–cell interactions, mechanical signaling, and matrix engineering

3D Bioprinting, Biofabrication & Organoids

• 3D bioprinting technologies, bioinks, and custom tissue constructs
• Organ-on-a-chip, microphysiological systems, and lab-grown tissues
• Organoids and spheroids for modeling development, disease, and drug response
• Multi-material bioprinting and vascularized tissue design
• Automation, robotics, and high-throughput tissue fabrication

Cellular Engineering, Gene Editing & Synthetic Biology

• Gene editing using CRISPR/Cas, base editing, prime editing
• Gene-modified stem cells and engineered tissue constructs
• Synthetic biology circuits for controlled cell behavior
• Genome manipulation, reprogramming, and lineage conversion
• Safety, off-target effects, and engineered-cell therapeutics

Tissue Development, Repair & Regeneration Biology

• Molecular mechanisms of tissue formation, patterning, and homeostasis
• Wound healing, fibrosis, and tissue repair pathways
• Angiogenesis, neurogenesis, osteogenesis, and chondrogenesis
• Mechanical forces, mechanobiology, and biophysical regulation
• Regeneration in model organisms and comparative regenerative biology

Stem Cell–Disease Interactions & Disease Modeling

• Stem cell models for cancer, genetic disorders, metabolic disease, and infection
• Cancer stem cells, tumor microenvironment, and metastasis mechanisms
• iPSC-derived disease models and precision medicine approaches
• Drug screening, toxicity testing, and functional assays
• Patient-specific and organ-specific disease modeling

Biomedical Engineering & Bioinstrumentation

• Microfluidics, biosensors, and lab-on-chip platforms
• Biomechanics of tissues and engineered constructs
• Real-time imaging, advanced microscopy, and molecular tracking
• Integrative engineering approaches for regenerative systems
• Computational modeling, simulation, and digital twin biology

Stem Cell Immunology & Cellular Interactions

• Immune regulation of stem cells and engineered tissues
• Host–graft interactions, rejection, and tolerance mechanisms
• Inflammatory microenvironments and regeneration failure
• Immune-based regenerative therapies
• Crosstalk between stem cells, stromal cells, and immune cells

Clinical Applications, Biotechnology & Industry

• Stem cell–based therapeutic development and commercialization
• Bioprocess engineering, cell expansion, and biomanufacturing
• Regulatory frameworks, biosafety, and ethical considerations
• Cryopreservation, cell banking, and quality control systems
• Industrial-scale tissue engineering and regenerative products

Emerging & Interdisciplinary Technologies

• AI/ML integration for stem cell analysis, fate prediction, and tissue design
• Spatial omics, single-cell sequencing, and multi-omics integration
• Nanotechnology for targeted delivery, sensing, and nanoscale tissue repair
• Wearable and implantable bioengineered systems
• Next-generation regenerative strategies and future innovations