Neural, Cardiac & Musculoskeletal Regeneration represents a critical frontier in regenerative medicine, targeting tissues with limited self-repair capacity. In neural regeneration, stem cells and biomaterials are used to restore function after spinal cord injuries, stroke, or neurodegenerative diseases by promoting neurogenesis, synaptic integration, and remyelination. Cardiac regeneration aims to repair myocardial damage from ischemic heart disease through the use of cardiomyocytes derived from stem cells, exosomes, or gene therapies to promote angiogenesis and restore contractility. Musculoskeletal regeneration focuses on bones, cartilage, tendons, and skeletal muscle, utilizing scaffolds, growth factors, and mesenchymal stem cells to heal injuries and degenerative conditions like osteoarthritis. Ongoing research integrates tissue engineering, bioactive materials, and 3D bioprinting to advance personalized, functional recovery for these complex tissue systems.