Biomaterials for tissue regeneration play a crucial role in advancing regenerative medicine by providing structural and biochemical support for the repair or replacement of damaged tissues and organs. These materials can be natural (e.g., collagen, chitosan, alginate) or synthetic (e.g., PLGA, PEG, PCL), and are engineered to mimic the extracellular matrix, promoting cell adhesion, proliferation, and differentiation. Ideal biomaterials are biocompatible, biodegradable, and mechanically suitable for the target tissue. They may also be functionalized with bioactive molecules, growth factors, or nanoparticles to enhance regenerative outcomes. Applications span a wide range of tissues, including bone, cartilage, skin, nerve, and cardiovascular structures. Ongoing research focuses on developing smart biomaterials with controlled release systems, responsiveness to biological stimuli, and enhanced integration, accelerating clinical translation and functional recovery.