Microbiome and genomic interaction explores how the trillions of microorganisms living in and on the human body influence health, disease, and personalized medicine. The gut, skin, oral, and respiratory microbiomes all interact closely with the host genome, affecting immune responses, metabolism, inflammation, and drug efficacy. By studying microbial DNA alongside human genetic data, researchers can uncover how microbial imbalances contribute to disorders such as obesity, diabetes, autoimmune diseases, neurodegenerative conditions, and cancer. Advances in metagenomics and sequencing technologies allow for precise identification of microbial species and their functional roles. Understanding these interactions also supports the development of targeted therapies, including probiotics, microbiome transplants, and personalized nutrition plans that align with individual genetic profiles.